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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Human maximisation test ： ウィキペディア英語版 Human maximisation test The Human maximisation test (HMT) is a test method for testing for contact allergens. It was first developed by Albert Kligman in 1966〔The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitizers http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html〕 and updated by Kligman and William Epstein in 1975.〔Kligman, A. M. and Epstein, W. (1975), Updating the maximization test for identifying contact allergens. Contact Dermatitis, 1: 231–239. doi: 10.1111/j.1600-0536.1975.tb05389.x〕 The first paper appeared 1966〔Kligman A. M. (1966) The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers. J. Invest. Dermatol. 47:393-409〕 and was a citation classic in 1985.〔http://garfield.library.upenn.edu/classics1985/A1985AUG6800001.pdf〕 The test uses human medical volunteers (usually 25) and sodium laureth sulphate to maximise. Because of the potentially large human reaction, it is generally not considered ethical to use today.〔http://ec.europa.eu/health/scientific_committees/consumer_safety/opinions/sccnfp_opinions_97_04/sccp_out102_en.htm〕 It does not have a guideline under the OECD Guidelines for the Testing of Chemicals. It has been compared with the murine local lymph node assay〔DA Basketter, EW Scholes, I Kimber (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food and chemical toxicology, 1994 - Elsevier〕〔Zaghi D, Maibach HI. (2009) The local lymph node assay compared with the human maximization test as an indicator of allergic potency in humans using patch test clinic populations. http://www.ncbi.nlm.nih.gov/pubmed/19514928〕 See also patch test. == References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Human maximisation test」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.